Global metabolic analyses of acinetobacter baumannii

Mahamad Maifiah, Mohd Hafidz and Velkov, Tony and Creek, Darren J. and Li, Jian (2019) Global metabolic analyses of acinetobacter baumannii. In: Acinetobacter baumannii. Humana Press, New York, pp. 321-328. ISBN 978-1-4939-9117-4

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Abstract

Acinetobacter baumannii is rapidly emerging as a multidrug-resistant pathogen responsible for nosocomial infections including pneumonia, bacteremia, wound infections, urinary tract infections, and meningitis. Metabolomics provides a powerful tool to gain a system-wide snapshot of cellular biochemical networks under defined conditions and has been increasingly applied to bacterial physiology and drug discovery. Here we describe an optimized sample preparation method for untargeted metabolomics studies in A. baumannii. Our method provides a significant recovery of intracellular metabolites to demonstrate substantial differences in global metabolic profiles among A. baumannii strains.

Item Type:	Book Chapter
Additional Information:	8219/71260
Uncontrolled Keywords:	Acinetobacter baumannii, Multidrug-resistant, Metabolomics, Polymyxins
Subjects:	Q Science > QR Microbiology R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	International Institute for Halal Research and Training (INHART)
Depositing User:	Dr Mohd Hafidz Mahamad Maifiah
Date Deposited:	26 Mar 2019 11:50
Last Modified:	12 Jul 2019 12:24
URI:	http://irep.iium.edu.my/id/eprint/71260

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