Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo

Wan Sulaiman, Wan Mohd. Azizi and Unal, Kevser (2018) Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo. In: 12th International Symposium on Pharmaceutical Sciences (ISOPS), 26 to 29th June 2018, Ankara, Turkey. (Unpublished)

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Abstract

Introduction: Derris trifoliata has been traditionally used as folk for the treatment of , rheumatic joints, diarrhoea, and dysmenorrhea, and rotenoids isolated from the plant have shown to exhibit anti-cancer properties. This study aimed to assess the toxicity effects and antiangiogenic activity of extract of Derris trifoliata on zebrafish embryo model. Materials and Methods: Zebrafihs embryos were treated with aqueous extract of Derris Trifoliata to evaluate its effects on angiogenesis and zebrafish-toxicity. Angiogenic response was analyzed using whole-mount alkaline phosphatase (AP) vessel staining on 72 hours post fertilization (hpf) zebrafish embryos. Results: 1.0 mg/ml concentration was toxic to zebrafish embryos and embryos exposed to concentrations at 0.5 mg/ml and below showed some malformations. Derris trifoliata aqueous extract also showed some anti-angiogenic activity in vivo in the zebrafish embryo model wereby at high concentration inhibited vessel formation in zebrafish embryo. Conclusions: The anti-angiogenic response of extract of Derris trifoliata in zebrafish in vivo model suggest its therapeutic potential as anti-cancer agent.

Item Type:	Conference or Workshop Item (Slide Presentation)
Additional Information:	4219/69896
Uncontrolled Keywords:	Derris trifoliata,zebra fish, anti angiogenesis
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM147 Administration of Drugs and Other Therapeutic Agents
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Basic Medical Sciences Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Wan Mohd Azizi Wan Sulaiman
Date Deposited:	24 Jan 2019 15:39
Last Modified:	24 Jan 2019 15:39
URI:	http://irep.iium.edu.my/id/eprint/69896

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