Prediction of mefenamic acid solubility and molecular interaction energies in different classes of organic solvents and water

Abdul Mudalip, Siti Kholijah and Abu Bakar, Mohd Rushdi and Jamal, Parveen and Adam, Fatmawati (2019) Prediction of mefenamic acid solubility and molecular interaction energies in different classes of organic solvents and water. Industrial & Engineering Chemistry Research, 58 (2). pp. 762-770. ISSN 0888-5885

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Abstract

Determination of solubility data either through experimental or model based approaches become a necessity in crystallization of pharmaceutical compound. The current work predicts the mefenamic acid solubility and molecular interaction energy, namely electrostatic (HMF), hydrogen bonding (H-HB) and van der Waals (H-vdW) in different solvents at temperatures from 298 to 323 K using Conductor-like Screening Model for Real Solvents (COSMO-RS). The solvents used were N, N-dimethylacetamide, N,N-dimethylformamide, acetone, ethyl acetate, ethanol, iso-propyl alcohol, n-hexane, n-heptane, cyclohexane and water. The Gibbs free energy of fusion required in COSMO-RS computation was determined using differential scanning calorimetry and reference solubility method. The accuracy of methods employed in prediction of solubility were evaluated using mean squared quadratic error (MSE). The mefenamic acid solubility predicted using COSMO-RS with reference solubility method showed a small MSE value, which was less than 2%. The predicted solubility also follows the same trend as the experimental values and increases with temperature. The predicted H-HB energy and Gibbs free energy changes of mefenamic acid dissolution in the solvents studied highly influence the solubility data. Therefore, COSMO-RS with reference solubility method is promising approach to predict solubility and intermolecular interaction energy of mefenamic acid in different solvents.

Item Type:	Article (Journal)
Additional Information:	4033/69833
Uncontrolled Keywords:	COSMO-RS, mefenamic acid, solubility, intermolecular interactions, Gibbs energy.
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology T Technology > TP Chemical technology > TP155 Chemical engineering
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering Kulliyyah of Engineering > Department of Biotechnology Engineering Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Mohd Rushdi Abu Bakar
Date Deposited:	18 Jan 2019 12:28
Last Modified:	31 Jul 2019 13:54
URI:	http://irep.iium.edu.my/id/eprint/69833

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