Antifilarial activity of the extract of leaves of Mimusops elengi Linn. on Setaria cervi in vitro

Ahmed, Qamar Uddin and Khan, Nizam Ud Din and Singhal, Kavita C. (2004) Antifilarial activity of the extract of leaves of Mimusops elengi Linn. on Setaria cervi in vitro. Journal of Veterinary Parasitology, 18. pp. 121-125. ISSN 0971-1031

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Abstract

Effect of aqueous and alcoholic extracts of the leaves of Mimusops elengi Linn. on the spontaneous movements of both the whole worm, the split preparation of Setaria cervi and on the survival of microfilariae in vitro was studied. Alcoholic extract of leaves caused inhibition of the spontaneous movements of the whole worm and the split preparation of S. cervi, while aqueous extract did not show any effect. The initial stimulatory effect was not observed by alcoholic extract of leaves on the spontaneous movements of whole worm as well as split preparation. The concentrations required to inhibit the movements of the whole worm and split preparation for alcoholic extract of leaves were 280 and 40 mg/ml, respectively, suggesting a cuticular permeability barrier. Alcoholic extract of leaves caused death of microfilariae in vitro. LC50 and LC90 were 15 and 25 ng/ml, respectively for alcoholic extract of leaves.

Item Type:	Article (Journal)
Additional Information:	4921/68953
Uncontrolled Keywords:	Miimusops elengi Linn. (Sapotsceae), Setaria servi, Microfilaricidal activity
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy
Depositing User:	Dr Qamar Uddin Ahmed
Date Deposited:	02 Jan 2019 08:31
Last Modified:	02 Jan 2019 08:31
URI:	http://irep.iium.edu.my/id/eprint/68953

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