Is asiaticoside effective against pain?

Mohammad, Rasyidah Ryta Ayumi and Shaik Mohamed Mossadeq, Wan Mastura and Zakaria, Zainul Amiruddin and Bakhtiar, M. Taher (2018) Is asiaticoside effective against pain? In: 15th Symposium of The Malaysian Society of Applied Biology, 29th June-1st July 2018, Melaka.

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Abstract

Centella asiatica or locally known as “Pegaga” is a well-known herb that has been used in folklore medicine for centuries to treat skin problem, asthma, sstomach disorder and to improve memory. Moreover, Centella asiatica extracts exhibited significant antinocicetive activities at the central and peripheral levels. This , this research aimed to evaluate the antinociceptive activities of asiaticoside, the main bioactive constituent of Centella asiatica. We evaluated the effect of asiaticoside (1,3,5 and 10 mg/kg, orally) on the acetic acid induced abdominal constriction test and the hot plate test in mice. Our data showed that the highest dose of asiticoside (10 mg/kg) significantly (p<0.05) inhibited the abdiomial constrictions by 58.3%. Moreover, asiaticoside prolongied the latency (sec) spent by each mouse on he hot plate surface. In conclusion, asiaticoside induces analgesia at the central and peripheral levels. Further studies are required to elucidate its mechanism(s) of action.

Item Type:	Conference or Workshop Item (Speech/Talk)
Additional Information:	5209/68950
Uncontrolled Keywords:	mice, asiaticoside, pain, analgesia
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Muhammad Taher
Date Deposited:	28 Dec 2018 16:29
Last Modified:	03 Jul 2019 15:28
URI:	http://irep.iium.edu.my/id/eprint/68950

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