Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome

Md Ralib, Azrina and Nanyan, Suhaila and Ramly, Nur fariza and Mat Nor, Mohd Basri (2018) Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome. Indian Journal of Critical Care Medicine, 22 (12). pp. 831-835. ISSN 0972-5229 E-ISSN 1998-359X

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Abstract

Introduction: Acute Kidney Injury (AKI) is common in the intensive care unit (ICU) with high risk of morbidity and mortality. The high incidence of AKI in our population may be attributed to sepsis. We investigated the incidence, risk factors and outcome of AKI in four tertiary Malaysian ICUs. We also evaluated its association with sepsis. Materials and Methods: This retrospective cohort study extracted de-identified data from the Malaysian Registry of Intensive Care in four Malaysian tertiary ICUs between January 2010 and December 2014. The study was registered under the NMRR and approved by the ethics committee. AKI was defined as twice the baseline creatinine or urine output < 0.5 ml/kg/h for 12 hours. Results: Of 26,663 patients, 24.2% had AKI within 24 hours of admission. Patients with AKI were older and had higher severity of illness compared to those without AKI. AKI patients had longer duration of mechanical ventilation, length of ICU and hospital stay. Age, SAPS II Score, and the presence of sepsis and preexisting hypertension, chronic cardiovascular disease independently associated with AKI. 32.3% had sepsis. Patients with both AKI and sepsis had highest risk of mortality (RR 3.43 (3.34 to 3.53)). Conclusions: AKI is common in our ICU, with higher morbidity and mortality. Independent risk factors of AKI include age, severity of illness, sepsis and preexisting hypertension, chronic cardiovascular disease. AKI independently contributes to mortality. The presence of AKI and sepsis increased the risk of mortality by three times.

Item Type:	Article (Journal)
Additional Information:	3934/68309
Uncontrolled Keywords:	Acute kidney injury in Malaysian; Intensive care setting; Incidences, risk factors and outcome
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care
Depositing User:	Prof Azrina Md Ralib
Date Deposited:	09 Jan 2019 15:56
Last Modified:	09 Nov 2020 16:46
URI:	http://irep.iium.edu.my/id/eprint/68309

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