Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves

Wan Ahmad, Wan Nadilah and Shaari, Khozirah and Khatib, Alfi and Abd hamid, Azizah and Hamid, Muhajir (2018) Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves. Pertanika Journal of Tropical Agricultural Science, 41 (3). pp. 1367-1381. ISSN 1511-3701 E-ISSN 2231-8542

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Abstract

Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world, including Malaysia. This study evaluated the bioactive potential of the leaf ethanolic extract and solvent fractions of Cosmos caudatus Kunth, in scavenging free radicals and inhibiting the enzyme α-glucosidase. In addition, their metabolite profiles were also characterized using liquid chromatography–mass spectrometry. The bioactivity was found to be concentrated in the EtOAc and BuOH fractions which largely contained rutin, quercetin 3-O-galactoside, quercetin 3-O-glucoside, quercetin 3-O-xyloside, quercetin 3-O-arabinofuranoside, quercetin 3-O-rhamnoside, and quercetin 3-O-galactoside, as profiled by LC-MS/MS. It was further shown that the flavonoids glycosides contributed to the free radical scavenging and glucose lowering effects of C. caudatus leaves. The results indicated that the leaves of C. caudatus are a rich source of bioactive compounds and could be prospective materials for development of new anti-diabetic agents.

Item Type:	Article (Journal)
Additional Information:	6915/66759
Uncontrolled Keywords:	alpha-glucosidase inhibition,Cosmos caudatus, free radical scavenging activity, LC-MSMS
Subjects:	R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. Alfi Khatib
Date Deposited:	18 Oct 2018 15:44
Last Modified:	23 Jan 2019 12:30
URI:	http://irep.iium.edu.my/id/eprint/66759

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