Evaluation of therapeutic effectiveness of prescribed medications in patients with type 2 diabetes mellitus: findings from a tertiary care hospital, Lahore, Pakistan

Rana, Bareera and Bukhsh, Allah and Khan, Tahir Mehmood and Sarwar, Ammar and Omer, Muhammad Ovais and Jamshed, Shazia Qasim (2017) Evaluation of therapeutic effectiveness of prescribed medications in patients with type 2 diabetes mellitus: findings from a tertiary care hospital, Lahore, Pakistan. Journal of Pharmacy and Bioallied Sciences, 9 (2 (April-June)). pp. 121-125. ISSN 0976-4879 E-ISSN 0975-7406

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Abstract

Aim: The present study was aimed to highlight the current prescribing pattern of oral hypoglycemia in type 2 diabetes mellitus and to evaluate the therapeutic effectiveness of these therapeutic categories in achieving target glycemic control. Methods: This is a prospective, cross-sectional, observational study of 6 months' duration conducted in a tertiary care hospital of Lahore, Pakistan. Results: The current research recruited 145 patients presented in diabetes management center of a tertiary care hospital in Lahore, Pakistan. Mean age of the participants was 50.2 (± 8.5) years. Out of the 145 patients, 63% were females and 37% were males. Most patients were diagnosed to have diabetes within the past 5 years. Diabetes-induced neuropathy was the most common complication (71.7%) among the patients. A large proportion of these patients (70.3%) were also suffering from other comorbidities among which the most common one is hypertension. The average number of prescribed medications was 1.31. Metformin was prescribed to a majority of patients (64%) as monotherapy while 28.96% received combination therapy. Mean glycated hemoglobin (HBA1c) before and after 3 months of treatment was 8.5 (± 2.3) and 8.04 (± 2.1), respectively. Inferential statistics show a strong association between HBA1c and life style modifications and adherence to medication therapy (P = 0.05). However, the correlation between HBA1c and Morisky score and duration of disease was inverse and weak (P = 0.6, 0.4). The t-test values show a small difference between HBA1c values before and after 3 months (t = 0.440 and 0.466, respectively). Conclusion: Optimization of medication regimen and continuous patient education regarding life style modification and adherence to medication therapy are necessitated to bring HBA1c values near to target

Item Type:	Article (Journal)
Additional Information:	6803/62851
Uncontrolled Keywords:	Diabetes mellitus; glycated; hemoglobin; Lahore; Morisky score; Pakistan; prescribing trends
Subjects:	R Medicine > RC Internal medicine R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User:	Dr Shazia Jamshed
Date Deposited:	06 Apr 2018 14:44
Last Modified:	25 Apr 2018 10:55
URI:	http://irep.iium.edu.my/id/eprint/62851

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