The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection

Mohd Jan, Nurul Hafiza and Zulkifly, Ahmad Hafiz and Ibrahim, Mohd Zulfadzli and Sha'ban, Munirah and Mohd Toff, Mohd Radzi (2019) The in-vitro and in vivo evaluations of orthopedic metal implant coated with silver composite: Potential treatment modality for implant related infection. In: Bio-CAM 2017 Conference on Biomedical & Advanced Material, 28th-29th November 2017, Langkawi, Kedah.

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Abstract

The prevalence of implant associated with infection remains high. The management of this incidence poses a major challenge in orthopedic field. Colonization of bacterial and biofilm adhesion on implant may lead to infection at underlying bone and surrounding tissues. The infection risks may be overcome by application of orthopaedic metallic implant coated with silver composite (OMICS) as alternative treatment of implant-infection related. The aimed of these studies were to evaluate the potential effect of orthopedic metal implant (plate) coated with silver composite through in vitro and in vivo experimental settings. Antimicrobial test through in vitro analysis indicated that OMICS showed excellent response of antibacterial agent against Staphylococcus aureus. The effects of OMICS on open fracture related with infection were assessed in New Zealand White Rabbit models. All rabbits were implanted with OMICS after six hours of tibial bone exposure. The implanted tibia was excised en bloc and evaluated by means of microbial assessments, radiography evaluation, gross inspection and histological analysis for any infection effects. After 3 weeks of implantation, microbial analysis revealed fewer colonies were noted at study group compared to control. By combining the radiograph, gross and histological data collected during the experimental follow up, there is no periosteal reaction noted at the surrounding on implanted area. The outcome of this study revealed positive response of the silver as antibacterial agent. These studies indicated that silver has antibacterial properties. In conclusion, these values suggested that orthopaedic metal implant coated with silver composite may have the potential to prevent implant related infections.

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	5828/61449
Uncontrolled Keywords:	Silver Coated Implant; Antibacterial Activity; Staphylococcus aureus; Medical Device-Related Infection; New Zealand White Rabbit
Subjects:	R Medicine > RD Surgery > RD701 Orthopedics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Physical Rehabilitation Sciences Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation Kulliyyah of Allied Health Sciences Kulliyyah of Medicine
Depositing User:	Mr. Mohd Zulfadzli Ibrahim
Date Deposited:	17 Jan 2018 15:42
Last Modified:	11 Oct 2019 09:04
URI:	http://irep.iium.edu.my/id/eprint/61449

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