In vivo evaluation of orthopaedic metal implant coated with silver composite: Potential treatment modality for implant related infection

Mohd Jan, Nurul Hafiza and Zulkifly, Ahmad Hafiz and Ibrahim, Mohd Zulfadzli and Sha'ban, Munirah (2017) In vivo evaluation of orthopaedic metal implant coated with silver composite: Potential treatment modality for implant related infection. In: 1st Postgraduate Symposium on Tissue Engineering and Regenerative Medicine 2017 (TERMSYMPO 2017), 7th November 2017, Cheras, Kuala Lumpur. (Unpublished)

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Abstract

The aimed of this study is to evaluate the potential effect of orthopaedic metal implant (plate) coated with silver composite in in vivo experiment setting using rabbit as animal model. Our hypothesis was that orthopaedic implant coated with silver would exert both bacteriostatic and bactericidal effects against certain microorganisms.With the approval from the Institutional Animal Care and Use Committee, all rabbits were randomly divided into two groups and underwent surgical procedure. In Group 1 (n=6), the right tibia was implanted with a silver-coated metal plate. While in Group 2 (n=6), the left tibia was implanted with a non-coated metal plate. The plates were implanted after six hours of tibial bone exposure. No antibiotics were administered. Animals were sacrificed at three weeks. The implanted tibia was excised en bloc and evaluated by means of microbial assessments, radiography evaluation, gross inspection and histological analysis for any infection effects. After 3 weeks of implantation, microbial analysis revealed fewer colonies were noted at study group compared to control. By combining the radiograph, gross and histological data collected during the experimental follow up, there is no periosteal reaction noted at the surrounding on implanted area. The outcome of this study revealed positive response of the silver as antibacterial agent.This study indicated that silver has antibacterial properties. This result suggested that orthopaedic metal implant coated with silver composite may have the potential to prevent implant related infections.

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	2397/61439
Uncontrolled Keywords:	orthopaedic metal implant, silver composite, implant related infection
Subjects:	R Medicine > RD Surgery > RD701 Orthopedics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation Kulliyyah of Allied Health Sciences > Department of Physical Rehabilitation Sciences
Depositing User:	Mr. Mohd Zulfadzli Ibrahim
Date Deposited:	17 Jan 2018 15:24
Last Modified:	17 Jan 2018 15:24
URI:	http://irep.iium.edu.my/id/eprint/61439

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