Antioxidant effects of some selected flavonoids: a structure-activity relationship based study

Sarian, Murni Nazira and Ahmed, Qamar Uddin and Mat So'ad, Siti Zaiton and Alhassan, A.M and Murugesu, Suganya and Perumal, Vikneswari and Syed Mohamed, S.N.A and Latif, J (2017) Antioxidant effects of some selected flavonoids: a structure-activity relationship based study. In: 2nd International Anatomical and Biomedical Scientific Conference 2017, 1-2 Aug 2017, Serdang, Selangor.

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Abstract

Objective: To investigate the antioxidant and radical scavenging activities of some selected flavonoids with respect to identify key positions responsible for antioxidant effects as well as the effect of derivatisation on the antioxidative effects. Design and method: Antioxidant potential was evaluated using different sets of assays viz., rapid test by dot blot, 1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ABTS+ radical cation scavenging, ferric reducing antioxidant powder (FRAP) and xanthine oxidase inhibitory (XOI) assays. Results: It was determined that the total number and the configuration of hydroxyl group play an important role in regulating bioactivity of flavonoids in scavenging DPPH radical, ABTS+ radical cation and FRAP assays. Presence of catechol and the absence of C-2-C-3 double bond as well as ketonic group at C-4 reduced the xanthine oxidase inhibitory activity. Methylation and acetylation of hydroxyl groups at particular positions were also found to decrease the in vitro bioactivity of flavonoids. Conclusions: The results of this study will further help to understand the role of flavonoids as natural antioxidants which might facilitate in the development of nutritional products and semi synthetic analogs that retain substantial antioxidant capacity with minimal adverse effects. Keywords: Flavonoids; antioxidant activity; derivatisation, structure activity relationship

Item Type:	Conference or Workshop Item (Lecture)
Additional Information:	4921/60999
Uncontrolled Keywords:	Flavonoids, antioxidant activity, derivatisation, structure activity relationship
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Qamar Uddin Ahmed
Date Deposited:	30 Dec 2017 23:53
Last Modified:	31 Dec 2017 23:18
URI:	http://irep.iium.edu.my/id/eprint/60999

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