Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls

Shalash, Ali and Salama, Mohamed and Makar, Marianne and Roushdy, Tamer and Elrassas, Hannan hany and Mohamed, Wael Mohamed Yousef and ElBalkimy, Mahmoud and Abu Donia, Mohamed (2017) Elevated serum α-synuclein autoantibodies in patients with Parkinson’s disease relative to Alzheimer’s disease and controls. Frontiers in Neurology, 8. pp. 1-6. ISSN 1664-2295

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Abstract

Early diagnosis of neurodegenerative diseases is of paramount importance for successful treatment. Lack of sensitive and early biomarkers for diagnosis of diseases like Parkinson’s disease (PD) is a handicapping problem for all movement disorders specialists. Using serum autoimmune antibodies (AIAs) against neural proteins is a new promising strategy to diagnose brain disorders through non-invasive and cost-effective method. In the present study, we measured the level of AIAs against α-synuclein (α-syn), which is an important protein involved in the pathogenesis of PD. In our study patients with PD (46 patients), Alzheimer’s disease (AD) (27 patients) and healthy controls (20 patients) were evaluated according to their sera α-syn AIAs levels. Interestingly, α-syn AIAs were significantly elevated in PD group compared to AD and healthy controls, which advocates their use for diagnosis of PD.

Item Type:	Article (Journal)
Additional Information:	7407/60803
Uncontrolled Keywords:	autoantibodies, biomarkers, α synuclein, Parkinson’s disease, Alzheimer’s disease
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine
Depositing User:	Dr Wael Mohamed
Date Deposited:	26 Dec 2017 16:27
Last Modified:	20 Apr 2018 12:23
URI:	http://irep.iium.edu.my/id/eprint/60803

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