Electrospun polycaprolactone nanofibres decorated by drug loaded chitosan nano- reservoirs for antibacterial treatments

Guarino, V and Cruz-Maya, Iriczalli and Altobelli, Rosaria and Abdul Khodir, Wan Khartini and Ambrosio, Luigi and Alvarez Pèrez, Marco A and Almaguer Flores, Argelia (2017) Electrospun polycaprolactone nanofibres decorated by drug loaded chitosan nano- reservoirs for antibacterial treatments. Nanotechnology, 28 (50). pp. 1-9. ISSN 0957-4484 E-ISSN 1361-6528

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Abstract

The main limitation of conventional antibiotic therapies concerns the low efficacy to fight bacteria attacks during long treatment times. In this context, the integrated use of electrofluidodynamics (EFDs)—basically electrospinning and electrospraying—may represent an interesting route for designing nanostructured platforms with controlled release to prevent the formation of bacterial biofilms in oral implant sites. They allow for the deposition of nanofibres and nanoparticles by different modes—i.e. sequential, simultaneous—for the fabrication of more efficacious systems in terms of degradation protection, pharmacokinetic control and drug distribution to the surrounding tissues. Herein, we will investigate EFDs processing modes and conditions to decorate polycaprolactone nanofibres surfaces by chitosan nano-reservoirs for the administration of Amoxicillin Trihydrate as an innovative antibacterial treatment of the periodontal pocket.

Item Type:	Article (Journal)
Additional Information:	6822/60451
Uncontrolled Keywords:	additive electrospraying, drug loaded nanoparticles, amoxycilin, antibacterial properties, fibre technology, biomaterials
Subjects:	T Technology > TA Engineering (General). Civil engineering (General) > TA166 Human engineering
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry
Depositing User:	WAN KHARTINI WAN ABDUL KHODIR
Date Deposited:	20 Dec 2017 04:21
Last Modified:	20 Apr 2018 12:14
URI:	http://irep.iium.edu.my/id/eprint/60451

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