A porous medium-chain-length poly(3-hydroxyalkanoates)/hydroxyapatite composite as scaffold for bone tissue engineering

Ansari, Nor Faezah and Annuar, Mohamad Suffian and Murphy, Belinda-pingguan (2017) A porous medium-chain-length poly(3-hydroxyalkanoates)/hydroxyapatite composite as scaffold for bone tissue engineering. Engineering in Life Sciences, 17 (4). pp. 420-429. ISSN 1618-0240 E-ISSN 1618-2863

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Abstract

Polyhydroxyalkanoates (PHA) are hydrophobic biopolymers with huge potential for biomedical applications due to their biocompatibility, excellent mechanical properties and biodegradability. A porous composite scaffold made of mediumchain- length poly(3-hydroxyalkanoates) (mcl-PHA) and hydroxyapatite (HA) was fabricated using particulate leaching technique and NaCl as a porogen. Different percentages of HA loading was investigated that would support the growth of osteoblast cells. Ultrasonic irradiation was applied to facilitate the dispersion of HA particles into the mcl-PHA matrix. The different P(3HO-co-3HHX)/HA composites were investigated using field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD) and energy dispersive X-ray analysis (EDXA). The scaffolds were found to be highly porous with interconnecting pore structures and the HA particles were homogeneously dispersed in the polymer matrix. The scaffolds biocompatibility and osteoconductivity were also assessed following the proliferation and differentiation of osteoblast cells on the scaffolds. From the results, it is clear that scaffolds made from P(3HO-co-3HHX)/HA composites are viable candidate materials for bone tissue engineering applications.

Item Type:	Article (Journal)
Additional Information:	AT352/60336
Uncontrolled Keywords:	Bone scaffold / Composite / Hydroxyapatite (30 %) / mcl-PHA / Porous biomaterial
Subjects:	Q Science > QH Natural history > QH301 Biology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science
Depositing User:	DR NOR FAEZAH ANSARI
Date Deposited:	04 Jan 2018 08:46
Last Modified:	21 Jun 2018 08:57
URI:	http://irep.iium.edu.my/id/eprint/60336

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