Abbas, Phirdaous and Hashim, Yumi Zuhanis Has-Yun and Amid, Azura
(2017)
Cytokinetic study of uninfected agarwood branch ethanolic extract on breast cancer cells.
Asia Pacific Journal of Molecular Biology and Biotechnology, 25 (1).
pp. 1-7.
ISSN 0128-7451
Abstract
Breast cancer is the most common malignancy in women with over 500,000 global death toll annually.
Ethnopharmaceutical practices provide evidences of Aquilaria spp. as traditional treatment for numerous illness. This study
intended to look into the cytotoxic kinetics of uninfected agarwood branch ethanolic extract from Aquilaria subintegra against
MCF-7 breast cancer cell line that could help grasp the effect and provide baseline towards development of agarwood-based
therapeutics. Extract was subjected to a series of kinetic studies in order to investigate the growth rate, death rate, doubling time
and death time of MCF-7 between the treated and control groups. Results obtained indicated that the extract lowered the growth
rate from 0.0421 h-1 to 0.0158 h-1 and stretched the doubling time from 16.4 hours to 43.8 hours. Death rate was escalated
from 0.0058 h-1 to 0.0563 h-1. Closer inspection on the population density images revealed that the extract-treated MCF-7 cells
showed abnormal appearance with blebs, volume reduction, cell shrinking and loss of cell-cell contact. These discoveries implied
that agarwood uninfected branch ethanolic extract altered the kinetics of MCF-7 cells and additional study should be made to
substantiate the hypothesis and elucidate the effects against cancer.
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