Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach

Ahmad, Siti Junaidah and Abdul Rahim, Mohd Badrin Hanizam and Baharum, Syarul Nataqain and Baba, Mohd Shukri and Mohamad Zin, Noraziah (2017) Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach. Journal of Tropical Medicine, 2017. pp. 1-7. ISSN 168-79686 E-ISSN 1687-9694

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Abstract

Natural products continue to play an important role as a source of biologically active substances for the development of new drug. Streptomyces, Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics. Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from these bacteria. However, this classical method in identifying potentially novel bioactive compounds from the natural products requires considerable effort and is a time-consuming process. Metabolomics is an emerging “omics” technology in systems biology study which integrated in process of discovering drug from natural products. Metabolomics approach in finding novel therapeutics agent for malaria offers dereplication step in screening phase to shorten the process. The highly sensitive instruments, such as Liquid Chromatography-Mass Spectrophotometry (LC-MS), Gas Chromatography-Mass Spectrophotometry (GC-MS), and Nuclear Magnetic Resonance (1 H-NMR) spectroscopy, provide a wide range of information in the identification of potentially bioactive compounds. The current paper reviews concepts of metabolomics and its application in drug discovery of malaria treatment as well as assessing the antimalarial activity from natural products. Metabolomics approach in malaria drug discovery is still new and needs to be initiated, especially for drug research in Malaysia.

Item Type:	Article (Journal)
Additional Information:	7342/59180
Uncontrolled Keywords:	antimalarial drugs, streptomycetes metabolites, metabolomic approach
Subjects:	R Medicine > RC Internal medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User:	Dr Mohd Shukri Baba
Date Deposited:	09 Nov 2017 11:52
Last Modified:	18 Apr 2018 12:10
URI:	http://irep.iium.edu.my/id/eprint/59180

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