Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms

Khan, J. A. and Abdul Rahman, Mohd Norhisham Azmi and Mazari, F. A. K. and Shahin, Y and Smith, G and Madden, L and Fagan, M. J. and Greenman, J and McCollum, P. T. and Chetter, I. C. (2012) Intraluminal Thrombus has a selective Influence on Matrix Metalloproteinases and Their inhibitors (tissue inhibitors of Matrix Metalloproteinases) in the wall of Abdominal Aortic Aneurysms. Annals of Vascular Surgery, 26 (3). pp. 322-329. ISSN 0890-5096 E-ISSN 1615-5947

PDF - Published Version Restricted to Repository staff only Download (519kB) | Request a copy

Abstract

Background: The influence of intraluminal thrombus (ILT) on the proteolytic environment within the wall of an abdominal aortic aneurysm (AAA) is unknown. This is the first study to examine the correlation between ILT thickness and the levels of matrix metalloproteinases (MMPs) and their natural inhibitors (tissue inhibitors of matrix metalloproteinases [TIMPs]) within the adjacent AAA wall. Methods: Thirty-five patients undergoing elective repair of AAAs were studied. A single full thickness infrarenal aortic sample was obtained uniformly from the arteriotomy site from each patient. All samples were snap frozen and analyzed for total and active MMP 2, 8, and 9 and TIMP 1 and 2. Thrombus thickness at the specimen site was measured on the preoperative contrast computed tomographic angiograms. Results: There was a statistically significant correlation between ILT thickness, concentration of TIMP 1, and active concentration of MMP 9. MMP 2 (active and total) and TIMP 2 demonstrated a positive correlation with ILT thickness, although not statistically significant. Conclusion: In this novel study, we found a significant positive correlation of ILT thickness with active MMP 9 and TIMP 1 concentration in the adjacent AAA wall, and this may have implications for AAA expansion and eventual rupture.

Item Type:	Article (Journal)
Additional Information:	6953/59158
Uncontrolled Keywords:	Intraluminal Thrombus, Selective Influence, Matrix Metalloproteinases, Tissue Inhibitors, Matrix Metalloproteinases, Abdominal Aortic Aneurysms
Subjects:	R Medicine > RD Surgery
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Surgery
Depositing User:	Dr M N A Abdul Rahman
Date Deposited:	13 Nov 2017 08:42
Last Modified:	12 Jan 2018 08:59
URI:	http://irep.iium.edu.my/id/eprint/59158

Actions (login required)

View Item