Extraction of α-glucosidase inhibitory compounds from Phaleria macrocarpa fruit flesh using solvent, sonication, and subcritical carbon dioxide soxhlet methods

Easmin, Sabina and Sarker, Md. Zaidul Islam and Ghafoor, Kashif and Ferdosh, Sahena and Jaffri, J. M. and Akanda, Md. Jahurul Haque and Al-Juhaimi, Fahad Y. and Bostanudin, M. Fauzi and Khatib, Alfi (2017) Extraction of α-glucosidase inhibitory compounds from Phaleria macrocarpa fruit flesh using solvent, sonication, and subcritical carbon dioxide soxhlet methods. Journal of Food Biochemistry, 41 (5). pp. 1-11. ISSN 0145-8884

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Abstract

The objective of this study was to compare a-glucosidase inhibitory activity of Phaleria macrocarpa extracts using subcritical carbon dioxide (subCO2) soxhlet extraction method with sonication and solvent extraction methods. The extraction was performed by subCO2 soxlet using carbon dioxide and the conventional organic solvent-based sonication using ethanol and water, solvent extraction using methanol, and n-hexane solvents. The yields and a-glucosidase inhibitory activity of the P. macrocarpa extracts were analyzed. The yields using sonication, solvent extraction, and subCO2 soxhlet extraction were approximately 10.261.0 to 25.460.6% and 0.960.1 to 2.061.0%. The IC50 value of subCO2 soxhlet, sonication, and solvent extraction methods were 4.35, 7.34, and 1.9 mg/mL, respectively. The a-glucosidase inhibitory activity of P. macrocarpa extract using subCO2 soxhlet method was higher than the conventional sonication method and lower than the solvent extraction method. Overall, subCO2 soxhlet extraction of P. macrocarpa represents a promising method to produce organic solvent free and highly a-glucosidase inhibitory compounds containing extracts.

Item Type:	Article (Journal)
Additional Information:	6605/59137
Uncontrolled Keywords:	a-glucosidase inhibitory activity, carbon dioxide soxhlet extraction, Phaleria macrocarpa, solvent extraction method, sonication method
Subjects:	R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. Alfi Khatib
Date Deposited:	07 Nov 2017 15:09
Last Modified:	25 Apr 2018 15:38
URI:	http://irep.iium.edu.my/id/eprint/59137

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