Statins effects on diabetic retinopathy among patients with Type 2 Diabetes Mellitus

Hammad, Mohamed Anwar and Mohamed Noor, Dzul Azri and Syed Sulaiman, Syed Azhar and Elsayed, Tarek Mohamed Ali (2017) Statins effects on diabetic retinopathy among patients with Type 2 Diabetes Mellitus. International Journal of Ophthalmology & Visual Science, 2 (4). pp. 106-114.

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Abstract

Diabetic Retinopathy (DR) is the leading cause of vision loss in adults aged 20–74 years. DR classified as the fifth most common cause of preventable blindness and fifth furthermost common cause of moderate to severe visual impairment. A retrospective cohort study was performed to evaluate the prevalence of DR, and the effect of statins on the DR, among outpatients with Type 2 diabetes mellitus. The study was done at the endocrine clinic in Hospital Pulau Pinang, Malaysia. Two cohorts of 717 diabetic outpatients (559 statins user and 158 statins non-users) were investigated for demographic data and diagnosis of DR. Findings were presented as descriptive statistics. The age of 717 subjects was (55.2±14.9) years and females 367 (51.2%). About 166 (23.2%) patients had DR with age (58.2±14.9) years. From 559 (78%) outpatients were statins-user, 143 (25.6%) had DR with age (58.5±14.9) years. While the control group 158 (22%) participants, only 23 (14.6%) had DR with age (56.3±14.9) years. The relative risk (RR) for DR in the statin-user group for DR is 1.75 and excessive relative risk (ERR) 75%. The absolute risk (AR) is 11% and number need to harm (NNH) is 9. Nearly one-quarter of the subjects had diabetic retinopathy. The risk of diabetic retinopathy incidence is higher in the statins user group than statins non-user cohort.

Item Type:	Article (Journal)
Additional Information:	6743/58625
Uncontrolled Keywords:	Eye, Malaysia, Diabetic Retinopathy, Statins, Type 2 Diabetes Mellitus
Subjects:	R Medicine > RE Ophthalmology R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User:	Mr. Tarek Elsayed
Date Deposited:	04 Oct 2017 08:56
Last Modified:	12 Jan 2018 15:55
URI:	http://irep.iium.edu.my/id/eprint/58625

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