Trends of strong opioid consumption in Malaysia and other Southeast Asian countries from 2005 to 2014

Zin, Che Suraya (2017) Trends of strong opioid consumption in Malaysia and other Southeast Asian countries from 2005 to 2014. In: 11th International Symposium on Pediatric Pain, 6-9 July 2017, Shangri-La Hotel Kuala Lumpur. (Unpublished)

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Abstract

Background and aims It was reported that opioid consumption in developing countries was stagnated or decreased but precise data on the consumption are unclear. This study examined the trends and patterns of opioid consumption in Malaysia and other Southeast Asian countries. Methods Data of five strong opioids consumption (morphine, oxycodone, fentanyl, pethidine and methadone) between 2005 and 2014 from Malaysia, Singapore, Indonesia, Thailand and Vietnam were extracted from the Pain & Policy Studies Group (PPSG). The PPSG is the WHO Collaborating Center for Pain Policy and Palliative Care that annually obtains opioid consumption data directly from the International Narcotics Control Board. The annual amount of opioid used was calculated as daily defined doses per 1000 inhabitants per day (DDD/1000 inhabitants/day) for each opioid in each country. Descriptive statistics and linear trend analysis were performed using Stata 13. Results Over a 10-year study period, the total opioid consumption in Malaysia (11.2 DDD/1000 inhabitants/day) was higher than that of Vietnam (2.22), Singapore (1.79), Thailand (0.98) and Indonesia (0.38). Vietnam had the largest increase (8454.79%, p<0.0001) in the total opioid consumption followed by Malaysia (993.18%, p<0.0001), Indonesia (137.75%, P>0.05), Singapore (113.08%, P<0.005) and Thailand (102.86%, p<0.0001). Ninety percents of the total opioid consumption in Malaysia (10.16 DDD/1000 inhabitants/day) was contributed by methadone which was mainly used in the opioid dependence program. For pain management, fentanyl was predominantly used in Malaysia (0.431 DDD/1000 inhabitants/day) but the greatest increase was for oxycodone (79.5%, p<0.0001). Conclusions Malaysia has the highest opiod consumption compared to the other four Southeast Asian countries, primarily for methadone. Although fentanyl was primarily used for pain management in Malaysia, the greatest increase was for oxycodone. Overall, all countries have demonstrated increasing trends of opioid consumption reflecting the improvement in the availability of opioid analgesics despite it being lower than global average. Acknowledgements C.S.Z was supported by a research grant from The Ministry of Education Malaysia (Fundamental Research Grant Scheme-FRGS 14-195-0436). The author would like to thank the Pain & Policy Studies Group for giving the permission to access the data.

Item Type:	Conference or Workshop Item (Plenary Papers)
Additional Information:	4127/57839
Uncontrolled Keywords:	Opioid consumption, trends, Malaysia, Southeast Asia, defined daily dose
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User:	Prof Dr Che Suraya Mohd Zin
Date Deposited:	01 Aug 2017 15:59
Last Modified:	01 Aug 2017 15:59
URI:	http://irep.iium.edu.my/id/eprint/57839

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