Modeling and analysis of a microresonating biosensor for detection of Salmonella bacteria in human blood

Bahadoran, Mahdi and Ahmad Noorden, Ahmad Fakhrurrazi and Chaudhary, Kashif and Mohajer, Faeze Sadat and Aziz, Muhammad Safwan and Hashim, Shahrin and Ali, Jalil and Yupapin, Preecha P. (2014) Modeling and analysis of a microresonating biosensor for detection of Salmonella bacteria in human blood. Sensor, 14 (7). pp. 12885-12899. ISSN 1424-8220

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Abstract

A new photonics biosensor configuration comprising a Double-side Ring Add-drop Filter microring resonator (DR-ADF) made from SiO2-TiO2 material is proposed for the detection of Salmonella bacteria (SB) in blood. The scattering matrix method using inductive calculation is used to determine the output signal’s intensities in the blood with and without presence of Salmonella. The change in refractive index due to the reaction of Salmonella bacteria with its applied antibody on the flagellin layer loaded on the sensing and detecting microresonator causes the increase in through and dropper port’s intensities of the output signal which leads to the detection of SB in blood. A shift in the output signal wavelength is observed with resolution of 0.01 nm. The change in intensity and shift in wavelength is analyzed with respect to the change in the refractive index which contributes toward achieving an ultra-high sensitivity of 95,500 nm/RIU which is almost two orders higher than that of reported from single ring sensors and the limit of detection is in the order of 1 × 10−8 RIU. In applications, such a system can be employed for a high sensitive and fast detection of bacteria.

Item Type:	Article (Journal)
Additional Information:	7730/55989
Uncontrolled Keywords:	nonlinear optics; microring resonator; biophotonics; biosensor; Salmonella bacteria
Subjects:	Q Science > QC Physics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science
Depositing User:	Dr Ahmad Fakhrurrazi Ahmad Noorden
Date Deposited:	21 Apr 2017 09:36
Last Modified:	21 Apr 2017 10:25
URI:	http://irep.iium.edu.my/id/eprint/55989

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