Identification of bioactive compounds with GC–Q-TOF–MS in the extracts from clinacanthus nutans using subcritical carbon dioxide extraction

Alam, Md. Ariful and Sarker, Md. Zaidul Islam and Ghafoor, Kashif and Ferdosh, Sahena and Asing, Md. Eaqub Ali and Mirhosseini, Hamed and Yunus, Kamaruzzaman and Jahurul, Md. Haque Akanda and Khatib, Alfi (2017) Identification of bioactive compounds with GC–Q-TOF–MS in the extracts from clinacanthus nutans using subcritical carbon dioxide extraction. Separation Science and Technology, 52 (5). pp. 852-863. ISSN 0149-6395 E-ISSN 1520-5754

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Abstract

Subcritical carbon dioxide Soxhlet extraction of biologically active compounds from Clincanthus nutans was investigated by full factorial design to identify and optimize the factors (particle size and co-solvent) affecting extract yield, antioxidant activity, total phenolic content, total flavonoid content, and α-glucosidase inhibitory activity. An average of 3.103% yield, 98.90% antioxidant activity, 49.40 mg/g (GAE) TPC, 43.76 mg/g (RE), and 88.58% AGI activity can be achieved using the optimum levels of independent variables. The GC Q-TOF MS identification of optimized extract shown that different classes of phytoconstituents were successfully separated by CO2-Soxhlet to produce potential antioxidant and α-glucosidase inhibitory activity.

Item Type:	Article (Journal)
Additional Information:	6605/55587
Uncontrolled Keywords:	α-glucosidase inhibitory activity, antioxidant,clinacanthus, nutans,subcritical carbon dioxide extraction
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Science > Department of Plant Science
Depositing User:	Dr. Sahena Ferdosh
Date Deposited:	28 Feb 2017 13:57
Last Modified:	22 Mar 2018 08:31
URI:	http://irep.iium.edu.my/id/eprint/55587

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