The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier

Kamato, Danielle and Rostam, Muhamad Ashraf and Bernard, Rebekah and Piva, Terence J. and Mantri, Nitin and Guidone, Daniel and Zheng, Wenhua and Osman, Narin and Little, Peter J. (2015) The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier. Cellular and Molecular Life Sciences, 72 (4). pp. 799-808. ISSN 1420-682X E-ISSN 1420-9071

	PDF - Published Version Restricted to Repository staff only Download (419kB) | Request a copy
	PDF (SCOPUS) - Published Version Restricted to Repository staff only Download (154kB) | Request a copy

Abstract

G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/ threonine kinase receptors, most notably the transforming growth factor-b receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the ‘‘triple membrane bypass’’ pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier.

Item Type:	Article (Review)
Additional Information:	7744/55279
Uncontrolled Keywords:	GPCR, Transactivation-dependent, Transactivation-independent, Cell signalling, G proteins, Rho/ROCK
Subjects:	Q Science > QP Physiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences
Depositing User:	Dr Muhamad Ashraf Rostam
Date Deposited:	23 Mar 2017 09:03
Last Modified:	23 Mar 2017 09:03
URI:	http://irep.iium.edu.my/id/eprint/55279

Actions (login required)

View Item