Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients

Mehde, Atheer Awad and Yusof, Faridah and Mehdi, Wesen Adel and Ahmed Raus, Raha and Othman Farhan, Layla and Zainulabdeen, Jwan Abdulmohsin and Zainal Abidin, Zaima Azira and Ghazali, Hamid and Abd Rahman, Azlina (2016) Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients. Asian Pacific Journal of Tropical Biomedicine, 7 (3). pp. 249-252. ISSN 2221-1691

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Abstract

Objective: To prove probable relations between serum E3 SUMO-protein ligase NSE2 (NSMCE2) concentration, peroxynitrite related to oxidative stress in nephrolithiasis patients. Methods: A total of 60 patients with nephrolithiasis and 50 healthy volunteers were involved in this study. Colorimetric method was used to detect blood urea, creatinine, uric acid, protein, albumin, total antioxidant status, total oxidant status, peroxynitrite, nitric oxide and oxidative stress index. Glutathione, NSMCE2 and superoxide dismutase were measured by ELISA. Results: A significant increase in level of peroxynitrite, total oxidant status, NSMCE2 and oxidative stress index in patients was observed, while total antioxidant status and glutathione were significantly decreased. Conclusions: The study concluded that serum NSMCE2 significantly correlated with peroxynitrite and oxidative stress in patients with nephrolithiasis.

Item Type:	Article (Journal)
Additional Information:	4416/54726
Uncontrolled Keywords:	Nephrolithiasis, peroxynitrite,nitric oxide, E3 SUMO-protein ligase NSE2, Total oxidant status
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering Kulliyyah of Science > Department of Biotechnology
Depositing User:	zaima azira zainal abidin
Date Deposited:	01 Feb 2017 11:35
Last Modified:	21 Feb 2017 15:51
URI:	http://irep.iium.edu.my/id/eprint/54726

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