Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger

Omar, Muhammad Nor and Hasali, Nor Hazwani and Yarmo, Mohd Ambar (2016) Cytotoxicity activity of biotransformed ethyl p-methoxycinnamate by Aspergillus niger. Oriental Journal of Chemistry, 32 (5). pp. 2732-2734. ISSN 0970-020X E-ISSN 2231-5039

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Abstract

The extraction of Kaempferia galanga rhizome using steam distillation and supercritical fluid extraction (SFE) was carried out. After fractionation, the major compound of the K. galanga extract, ethyl p-methoxycinnamate (EPMC) was transformed using Aspergillus niger into ethyl p-hydroxycinnamate (EPHC). The biological anticancer activity of EPMC and its biotransformed product (EPHC) was established by cytotoxicity activity on the human breast cancer (MCF-7) cell line using MTT assay. Ethyl p-hydroxycinnamate (EPHC) was most cytotoxic against MCF-7 at 1000 μg/mL where percentage of cell viability was 9.87 %, while IC50 was 340 μg/mL. EPHC showed slightly higher cytotoxicity activity compared to EPMC. The results of this study show that the biotransformation process was able to produce a metabolite (EPHC) with higher cytotoxicity activity compared to its parent compound (EPMC).

Item Type:	Article (Journal)
Additional Information:	5626/54229
Uncontrolled Keywords:	Kaempferia galanga, ethyl p-methoxycinnamate, biotransformation, cytotoxic.
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Biotechnology
Depositing User:	Prof Dr Muhammad Nor Omar
Date Deposited:	16 Jan 2017 10:26
Last Modified:	21 Nov 2017 17:17
URI:	http://irep.iium.edu.my/id/eprint/54229

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