Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract

Mediani, Ahmed and Abas, Faridah and Maulidiani, H. and Khatib, Alfi and Tan, Chin Ping and Ismail, Intan Safinar and Shaari, Khozirah and Ismail, Amin and Lajis, Nordin H. (2016) Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract. Journal of Pharmaceutical and Biomedical Analysis, 128. pp. 302-312. ISSN 0731-7085

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Abstract

Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes. Phyllanthus niruri has been used as a treatment for diabetes mellitus. Herein, the induction of type 2 diabetes in Sprague–Dawley rats was achieved by a low dose of streptozotocin (STZ) (25 mg/kg bw). Here, we evaluated the in vivo antidiabetic properties of two concentrations (250 and 500 mg/kg bw) of P. niruri via metabolomics approach. The administration of 500 mg/kg bw of P. niruri extract caused the metabolic disorders of obese diabetic rats to be improved towards the normal state. The extract also clearly decreased the serum glucose level and improved the lipid profile in obese diabetic rats. The results of this study may contribute towards better understanding the molecular mechanism of this medicinal plant in managing diabetes mellitus.

Item Type:	Article (Journal)
Additional Information:	6915/53494 Please upload published version article.
Uncontrolled Keywords:	Phyllanthus niruri; 1H NMR-based metabolomics; Diabetes mellitus; Multivariate data analysis; Metabolic pathway
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. Alfi Khatib
Date Deposited:	13 Dec 2016 18:40
Last Modified:	04 Jan 2017 12:15
URI:	http://irep.iium.edu.my/id/eprint/53494

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