Antilipase and antioxidant activity of Phyllanthus niruri ethanolic extract

Raja Abd. Rahman, Raja Noor Zaliha and Alias, Norsyuhada and Thean, Chor Leow and Mohamad Ali, Mohd. Shukuri and Ahmad Tajudin, Asilah and Salleh, Abu Bakar (2015) Antilipase and antioxidant activity of Phyllanthus niruri ethanolic extract. Australian Journal of Basic and Applied Sciences, 9 (7). pp. 639-643. ISSN 1991-8178

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Abstract

The aim of this study is to determine the antilipase and antioxidant activity of Phyllanthus niruri methanolic extract. The inhibitory activity against porcine pancreatic lipase (PPL) was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol at 405 nm. The crude extract exhibited strong lipase inhibitory activity with an IC50 value of 27. 65 µg/ mL. The inhibition mode study disclosed that P. niruri could act as noncompetitive inhibitor. Antioxidant activity of P. niruri extract was measured by 2, 2, diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity assay. P. niruri showed high antioxidant activity with an EC50 value of 7.471 µg/mL. The results suggested that P. niruri has shown potential as a source of natural antilipase and antioxidant.

Item Type:	Article (Journal)
Additional Information:	7690/53232
Uncontrolled Keywords:	Antilipase and antioxidant, phyllanthus niruri, methanolic extract
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011)
Depositing User:	Norsyuhada Alias
Date Deposited:	01 Dec 2016 15:32
Last Modified:	01 Dec 2016 15:32
URI:	http://irep.iium.edu.my/id/eprint/53232

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