Cytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae)

On, Shamsul and Wan Salleh, Wan Mohd Nuzul Hakimi and Ahmad, Farediah and Sirat, Hasnah M and Bakhtiar, M. Taher (2017) Cytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae). Marmara Pharmaceutical Journal: an international peer-reveiwed open acces journal of pharmacy and pharmaceutical sciences., 21 (1). pp. 127-131. ISSN 1309-0801

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Abstract

Phytochemical investigation of the leaves of Garcinia prainiana resulted in the isolation of five triterpenes identified as squalene 1, friedelin 2, lupeol 3, 3β-hydroxyeupha-5,22-diene 4, and 3β-acetoxyeupha-5,22-diene 5. The structures of these compounds were established by analysis of their spectroscopic data, as compared to that of reported compounds. All compounds were tested for cytotoxicity against H1299 and A549 lung cancer cell lines using MTT assay. 3β-Acetoxyeupha-5,22-diene 5 exhibited the most significant activity against human non-small cell lung carcinoma cell lines, H1299 and A549 with IC50 values 18.0 μg/ml and 36.3 μg/ml, respectively.

Item Type:	Article (Journal)
Additional Information:	5209/52129
Uncontrolled Keywords:	Triterpene,garcinia prainiana,cytotoxicity
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Muhammad Taher
Date Deposited:	07 Oct 2016 14:49
Last Modified:	17 Apr 2018 15:27
URI:	http://irep.iium.edu.my/id/eprint/52129

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