Antimicrobial activity of three hard coral species from South China Sea (Malaysia)

Qaralleh, Haitham and Idid, Syed Zahir and Saad, Shahbudin and Susanti , Deny and Althunibat, Osama Yousef and Sheikh, Hasan I (2014) Antimicrobial activity of three hard coral species from South China Sea (Malaysia). SYLWAN Journal, 158 (4). pp. 20-25. ISSN 0039-7660

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Abstract

The problem of antimicrobial drug resistance has necessitated a search for new antimicrobial substances from other sources including natural sources. Marine organisms are known to produce metabolites to protect themselves against pathogens and therefore can be considered as a potential source of antimicrobial substances. This study designed to evaluate the antimicrobial activity of three hard coral species namely Favites sp Link (Faviidae), Galaxea fascicularis Linnaeus (Oculinidae), and Galaxea astreata Lamarck (Oculinidae) against six pathogenic microbes. The coral species were extracted with water and a combination of dichloromethane and methanol. The antimicrobial activity of the extracts was evaluated using disc diffusion method and microdilution method. From the disc diffusion method, the organic extracts showed antimicrobial activity while the aqueous extracts showed no activity. The organic extract from G. fascicularis was the most effective against Staphylococcus aureus (11 mm) and Bacillus cereus (10.5 mm). From the microdilution method, the organic extracts of G. fascicularis and G. astreata showed inhibitory effect against S. aureus and B. cereus at low concentrations (0.003 - 0.1 mg/mL). However, complete growth inhibitions of S. aureus and B.cereus were observed for the organic extract of G. fascicularis at concentrations of 0.34 and 1.1 mg/mL, respectively. Further studies must be conducted to isolate the antimicrobial compounds from the G. fascicularis, which may contribute towards finding compounds for the treatment of infectious diseases.

Item Type:	Article (Journal)
Additional Information:	4333/50322
Uncontrolled Keywords:	Antibacterial, Antifungal, Favites sp, Galaxea fascicularis, Galaxea astreata
Subjects:	Q Science > QR Microbiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Biomedical Science Kulliyyah of Science > Department of Biotechnology Kulliyyah of Science > Institute of Oceanography and Maritime Studies
Depositing User:	PROF SYED ZAHIR IDID
Date Deposited:	09 Jun 2016 14:25
Last Modified:	08 Jan 2018 16:06
URI:	http://irep.iium.edu.my/id/eprint/50322

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