Cytotoxic and antibacterial activities of constituents from Calophyllum ferrugineum ridley

Aminudin, Nurul Iman and Ahmad, Farediah and Bakhtiar, M. Taher and Mohamed Zulkifli, Razauden (2016) Cytotoxic and antibacterial activities of constituents from Calophyllum ferrugineum ridley. Records of Natural Products, 10 (5). pp. 649-653. ISSN 1307-6167

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Abstract

This study evaluated the chemical composition of Calophyllum ferrugineum, cytotoxicity against human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines as well as antibacterial activities against two Gram-positive bacteria, S. aureus and B. subtilis and two Gram-negative bacteria, P. aeruginosa and E. coli. Phytochemical investigations of the bark extract yielded isoapetalic acid (1), apetalic acid (2), 6-hydroxy-2-methoxyxanthone (3) and ent-epicatechin (4). Meanwhile, betulinic acid (5), protocatechuic acid (6) and amentoflavone (7) were isolated from the leave extract. Isoapetalic acid (1) and apetalic acid (2) exhibited cytotoxic activities towards both cancer cell lines and both Gram-positive bacteria. Compounds (3-7) were inactive or showed moderate activities towards cytotoxic and antibacterial tests. This study presents the first report on the phytochemicals investigation from C. ferrugineum and all compounds are reported for the first time from this source.

Item Type:	Article (Journal)
Additional Information:	5209/50076
Uncontrolled Keywords:	Calophyllum ferrugineum, cytotoxic activities, antibacterial activities
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Muhammad Taher
Date Deposited:	12 Apr 2016 09:47
Last Modified:	10 Apr 2017 15:41
URI:	http://irep.iium.edu.my/id/eprint/50076

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