Significance of palpitation among hypertensive patients receiving captopril

Marbut, Mossa M. and K. Rajab, Hassan and Al-Mahmood, Sinan (2009) Significance of palpitation among hypertensive patients receiving captopril. Medical Journal of Tikrit, 15 (2). pp. 32-37. ISSN 1683-1813

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Abstract

Captopril prevent the conversion of angiotensin 1 to II by inhibiting of peptidyl dipeptide carboxy hydrolase enzyme. Captopril is an angiotensin converting enzyme (ACE) inhibitors which is the treatment of hypertension. Hundred & eight hypertensive patients taking captoprill as a tablet 25 mg twice daily (47 men & 61 women). Each patient had a complete history detailed, physical examination, all patients were interviewed & full medical history was taken. All patients were questioned about the presence or absence of headache, palpitation, cough, flushing, chest pain, dysgeusia & tachycardia. Blood pressure & heart rate were measured for each patient each visit. In hypertensive men, 29 patients out of 47 (61.7%), hypertensive patients are diagnosed as suffering from palpitation. While in hypertensive women, 39 patients out of 61 women have palpitation after taking captopril for 3 months (64%). In regard to serum potassium, it was estimated in 51 hypertensive patients (27 with palpitation & 24 patients without palpitation). There is no significant difference in regarded to serum potassium between hypertensive patients with palpitation & hypertensive patients without palpitation. In hypertensive patients with palpitation, 9 patients out of 27 patients have hyperkalaemia (33.3%), (serum potassium more than 3 mmol/L). In hypertensive patients without palpitation, only 3 patients out of 24 patients have hyperkalaemia (0.125%). In hypertensive men, there are no significant differences between group with palpitation & patients without palpitation regarding blood pressure in both systolic & diastolic. Also, there is no significant difference regarding heart rate between group of patients with palpitation & group of patients without palpitation. Palpitation can be attributed to one of the three main causes. The first cause is hyperdynamic circulation which includes hypercapnia, pyrexia, thyrotoxicosis, anemia & pregnancy. The second cause is sympathetic overdrive include panic disorders, hypoglycemia, hypoxia, heart failure & mitral valve prolapse. While the third main cause is arrhythmias.

Item Type:	Article (Journal)
Additional Information:	7037/47660
Uncontrolled Keywords:	Captopril, hypertension, palpatitation, blood pressure, tachycardia
Subjects:	R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Nursing
Depositing User:	Mr SINAN AL-MAHMOOD
Date Deposited:	17 Mar 2016 08:53
Last Modified:	20 Jun 2017 11:25
URI:	http://irep.iium.edu.my/id/eprint/47660

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