Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea Bearing α- and β-alanine

Ngah, Nurziana and Mohamed, Nor Azanita and Darnis, Deny Susanti (2016) Synthesis, Characterization and Antioxidant Activity of 2-Halobenzoyl Thiourea Bearing α- and β-alanine. Chiang Mai Journal of Science, 43 (3). pp. 577-583. ISSN 0125-2526

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Abstract

Six new 2-halobenzoylthiourea compounds bearing α- and β-alanine have been successfully synthesized and characterized using CHNS microelemental analysis and spectroscopic methods including FTIR, UV-Vis and NMR. Microelemental analysis data of the compounds were in agreement with the theoretical values. The FTIR spectra showed the presence of important bands of the compounds while the 1 H-NMR and 13C-NMR exhibited the expected chemical shifts. The compounds exerted weak antioxidant activity in DPPH scavenging test and moderate to good activity in β-carotene bleaching test. The inclusion of halogen atoms has facilitated the released of hydrogen atoms and introduction of α- and β-alanine have increased the β-carotene bleaching and DPPH scavenging activities of the compounds.

Item Type:	Article (Journal)
Additional Information:	5777/46121
Uncontrolled Keywords:	2-halobenzoyl thiourea, alanine and antioxidant
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Nurziana Ngah
Date Deposited:	06 Jan 2016 11:04
Last Modified:	12 Oct 2017 13:22
URI:	http://irep.iium.edu.my/id/eprint/46121

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