Polymeric behavior evaluation of PVP K30- poloxamer binary carrier for solid dispersed nisoldipine by experimental design

Kyaw Oo, May and Mandal, Uttam Kumar and Chatterjee, Bappaditya (2015) Polymeric behavior evaluation of PVP K30- poloxamer binary carrier for solid dispersed nisoldipine by experimental design. Pharmaceutical Development Technology. pp. 1-11. ISSN 1083-7450 (P) 1097-9867 (O) (In Press)

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Abstract

Context: High melting point polymeric carrier without plasticizer is unacceptable for solid dispersion (SD) by melting method. Combined polymer–plasticizer carrier significantly affects drug solubility and tableting property of SD. Objective: To evaluate and optimize the combined effect of a binary carrier consisting PVP K30 and poloxamer 188, on nisoldipine solubility and tensile strength of amorphous SD compact (SDcompact) by experimental design. Materials and methods: SD of nisoldpine (SDnisol) was prepared by melt mixing with different PVP K30 and poloxamer amount. A 32 factorial design was employed using nisoldipine solubility and tensile strength of SDcompact as response variables. Statistical optimization by design expert software, and SDnisol characterization using ATR FTIR, DSC and microscopy were done. Results: PVP K30:poloxamer, at a ratio of 3.73:6.63, was selected as the optimized combination of binary polymeric carrier resulting nisoldipine solubility of 115 mg/mL and tensile strength of 1.19 N/m2 . Discussion: PVP K30 had significant positive effect on both responses. Increase in poloxamer concentration after a certain level decreased nisoldipine solubility and tensile strength of SDcompact. Conclusion: An optimized PVP K30–poloxamer binary composition for SD carrier was developed. Tensile strength of SDcompact can be considered as a response for experimental design to optimize SD.

Item Type:	Article (Journal)
Additional Information:	6923/46058
Uncontrolled Keywords:	Factorial design, nisoldipine, solid dispersion, solubility
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Bappaditya Chatterjee
Date Deposited:	09 Dec 2015 09:44
Last Modified:	19 Jan 2018 11:03
URI:	http://irep.iium.edu.my/id/eprint/46058

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