Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy

Ali, Yousaf and Abd Hamid, Shafida (2016) Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy. Tumor Biology, 37 (1). pp. 1-9. ISSN 1010-4283 E-ISSN 1423-0380

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Abstract

Topoisomerases are nuclear enzymes that regulate topology of DNA by facilitating the temporary cleavage and ligation cycle of DNA. Among all forms of topoisomerases, TOP-IIA is extensively associated with cell proliferation and therefore is an important therapeutic target in diseases that involved cellular proliferation such as cancers. Nearly half of present-day antitumor regimens contain at least one prescription that act as a topoisomerase inhibitor. Generally, tumor cells show divergent expression of TOP-IIA compared to normal cells. The remarkable expression of TOP-IIA in various carcinomas provides a significant biomarker toward understanding the nature of malignancy. TOP-IIA expression and amplification studies help in diagnosing cancer and to observe the disease progression, overall survival (OS) of patients, and response to therapy. This review highlights the research output and analysis in exploring the standing of TOP-IIA in various carcinomas. As some reports show contradiction within the same field of interest, the outline of that may help to induce researchers for further investigation and clarification. To the best of our knowledge, this is the first overview briefly summarizing the prognostic feature of TOP-IIA in various types of cancer.

Item Type:	Article (Journal)
Additional Information:	5980/45324
Uncontrolled Keywords:	Topoisomerase II alpha, Prognosis, Biomarker Cancer
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Shafida Abd Hamid
Date Deposited:	01 Mar 2016 13:10
Last Modified:	18 Jul 2017 14:52
URI:	http://irep.iium.edu.my/id/eprint/45324

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