Polymer selection for nisoldipine solid dispersion to enhance solubility

Kyaw Oo, May and Chatterjee, Bappaditya (2015) Polymer selection for nisoldipine solid dispersion to enhance solubility. In: 4th International Conference on Pharmaceuticals, Nutraceuticals and Cosmetic Science (UPNaCS 2015), 12th-13th Nov. 2015, Ramada Plaza, Melaka. (Unpublished)

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Abstract

Nisoldipine is a very potent calcium channel blocker which is used as anti-hypertensive agent. Although it is prescribed widely as oral tablet, its use has been limited due to poor bioavailability which arises from its poor water solubility. Hot Melt solid dispersion of poorly water-soluble drug in long chain polymer is a common approach to enhance solubility and bioavailability. However, there is only little data available on the selection of polymer type and ratio which are critical parameters for solid dispersion. The present study aimed to compare the effect of different polymers on nisoldipine solid dispersion and to investigate the type and range of polymers with optimum nisoldipine solubility.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	6923/45273
Uncontrolled Keywords:	solid dispersion, polymers, nisolpidine, solubility
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Bappaditya Chatterjee
Date Deposited:	07 Jan 2016 15:24
Last Modified:	21 Jun 2018 10:47
URI:	http://irep.iium.edu.my/id/eprint/45273

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