Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions

Abdul Jabbar, Omar and Mustafa Al-Ahmad, Basma Ezzat and Faisal, Ghasak Ghazi (2015) Immunoexpression of TGF-b in giant cell tumour, central and peripheral giant cell lesions. In: FDI 2015 - Annual World Dental Congress, 22-25 Sep 2015, Bangkok.

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Abstract

Aim and purpose: To investigate the difference in biological behavior between Giant Cell Lesion in oral cavity with Giant Cells tumors in long bones by using transforming growth factor beta (IHC) marker. Materials and method: Total of 40 cases of giant cell lesions (C.G.C.G., P.G.C.G. and G.C.T) were included in this study. 17 cases were of G.C.T, 14 of C.G.C.G. and 9 cases were of P.G.C.G. Immunohistochemical staining technique by TGF-b marker was conducted upon these cases showing positive expression in both multinucleated giant cells (MGC) and mononucleated stromal cells (MC) which are considered to be the main histopathological constituent of giant cell lesions.Results: The PGCL showed lightly higher expression of TGF B1 in (MC) than CGCL and GCT but with a non-significant difference value. In comparison of PGCL and CGCL with GCT, they showed higher expression of TGF-b in MGC (p < 0.05). Summary and conclusions: Our results suggest that, in CGCL and PCGL the TGF-b may be important for osteoclastogenesis and bone resorption.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	7092/45156
Uncontrolled Keywords:	biological behavior, Giant Cell Lesion, oral cavity, Giant Cells tumors, long bones, transforming growth factor beta (IHC) marker
Subjects:	R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry
Depositing User:	Dr Omar Abdul jabbar
Date Deposited:	26 Oct 2015 11:59
Last Modified:	23 May 2016 11:32
URI:	http://irep.iium.edu.my/id/eprint/45156

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