Cytotoxic study of Linum usitatissimum and Salvia officinallis extracts on MCF-7 cell line (comparative study)

Shaban, Sama and Ichwan, Solachuddin J. A. and Mustafa Al-Ahmad, Basma Ezzat and Kashmola, Muhanad Ali Hamdon and Mustafa, Nazih Shaban and Taher, Muhammad (2015) Cytotoxic study of Linum usitatissimum and Salvia officinallis extracts on MCF-7 cell line (comparative study). In: International Conference on Advancement in Science and Technology (iCAST 2015) - ‘Frontiers in Biotechnology’, 10-12 Aug 2015, Impiana Resort Cherating, Pahang, Malaysia. (Unpublished)

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Abstract

Salvia officinallis and linum usitatissimum are two natural extracts that have been studied before and resulted to have many beneficial values, the research experiment we have done was to investigate weather both of the extracts possess anticancer activities on breast cancer MCF-7 cell line. The MCF.7 cell line was maintained in Dulbecco’s Minimum Essential Medium (DMEM), supplemented with 10% fetal bovine serum (FBS) and 1% of penicillin and grown in 6 cm2 tissue culture dishes. A colorimetric MTT (3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay was used to indicate the cell viability. The MTT test results have shown a slight gradual distraction of breast cancer cells by salvia officinallis oil and water extracts, for linum usitatissimum both oil and water extract have shown little to no growth constriction to MCF-7 breast cancer cells. In this experiment linum usitatissimum showed no cytotoxicity effects on MCF-7 in its both water and oil forms. As for Salvia officinallis there was a little growth constriction effects by its both water and oil extracts on MCF-7 cell line.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	5731/44448
Uncontrolled Keywords:	MCF-7, Salvia officinallis, Linum usitatissimum, MTT
Subjects:	Q Science > Q Science (General) R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry
Depositing User:	Dr Basma Al-Ahmad
Date Deposited:	07 Oct 2015 11:41
Last Modified:	21 May 2018 15:03
URI:	http://irep.iium.edu.my/id/eprint/44448

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