Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine

Mohamed, Nor Azanita and Ngah, Nurziana and Darnis, Deny Susanti (2014) Synthesis, characterisation and antimicrobial activity of fluorobenzoylthioureas bearing a- and b-alanine. In: International Conference on Natural Products 2014 (ICNP 2014), 18th-19th March 2014, Palm Garden Hotel, IOI Resorts, Putrajaya, Malaysia. (Unpublished)

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Abstract

A series of fluorobenzoylthioreas bearing a- and b- alanine with different position of fluoro atom substitution have been successfully synthesised and characterised using CHNS micro elemental analysis and spectroscopic method including FTIR, UV-Vis and 1H and 13C NMR. Microelemental analysis data of the compounds were in agreement with the calculated values. The FTIR spectra showed the presence of important bands of the compounds and 1H and 13C exhibited expected chemical shift. Antibacterial and anti fungal activities have been evaluated by zone of inhibition, MIC and MBC/MFC studies against B.cereus, S.epidermidis, E. coli, P.aeruginosa, C. Albicans and T. metagrophytes. Most of the compounds showed moderate antibacterial activity against B.cereus and S.epidermidis and moderate to excellent anti fungal activity against T.metagrophytes. The antimicrobial activities of the compounds were related to the different position of fluoro atom substitution and a-and b-alanine presence in the compounds

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	5777/41262
Uncontrolled Keywords:	fluorobenzoylthioureas bearing a- and b-alanine
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Nurziana Ngah
Date Deposited:	12 Feb 2015 11:56
Last Modified:	19 Jun 2018 16:33
URI:	http://irep.iium.edu.my/id/eprint/41262

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