Antimalarial activity of Neopetrosia exigua extract in mice

Abdillah, Syamsudin and Ahmad, Rahmatul Wahidah and Muzaki, Farid Kamal and Mohd Noor, Noriah (2013) Antimalarial activity of Neopetrosia exigua extract in mice. Journal of Pharmacy Research , 6 (8). pp. 799-803. ISSN 0974-6943

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Abstract

Objective: To evaluate the antimalarial activity of ethanolic extract of Neopetrosia exigua in ICR mice. The safety of the extracts was also ICR mice by the acute oral toxicity test. Methods: The crude ethanol extract of Neopetrosia exigua (50, 100, 200 and 400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei during early infection. The acute toxicity of the extract was also investigated. At the end of 14 days, mice were sacrificed for histopathology study. Results: The extract of Neopetrosia exigua demonstrated significant ( p <0.05) schizonticidal activity. The acute toxicity test showed that the extract of Neopetrosia exigua is toxicological safe by oral administration. Histopathological study revealed normal architecture of kidney and liver of mice.

Item Type:	Article (Journal)
Additional Information:	3960/39965
Uncontrolled Keywords:	Neopetrosia exigua, Ethanolic extract, Antimalarial activity, cute toxicity
Subjects:	R Medicine > RC Internal medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Basic Medical Sciences
Depositing User:	Prof Noriah Mohd Noor
Date Deposited:	16 Dec 2014 11:02
Last Modified:	16 Dec 2014 11:02
URI:	http://irep.iium.edu.my/id/eprint/39965

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