Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation

Yagi, Hideshi and Nagano, Takashi and Xie, Min-Jue and Ikeda, Hiroshi and Kuroda, Kazuki and Komada, Munekazu and Iguchi, Tokuichi and Rahman, Mohammad Tariqur and Morikubo, Soichi and Noguchi, Koichi and Murase, Kazuyuki and Okabe, Masaru and Sato, Makoto (2014) Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation. Scientific Reports, 4 (6353). pp. 1-13. ISSN 2045-2322

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Abstract

Learning and memory depend on morphological and functional changes to neural spines. Non-muscle myosin 2b regulates actin dynamics downstream of long-term potentiation induction. However, the mechanism by which myosin 2b is regulated in the spine has not been fully elucidated. Here, we show that filamin A-interacting protein (FILIP) is involved in the control of neural spine morphology and is limitedly expressed in the brain. FILIP bound near the ATPase domain of non-muscle myosin heavy chain IIb, an essential component of myosin 2b, and modified the function of myosin 2b by interfering with its actin-binding activity. In addition, FILIP altered the subcellular distribution of myosin 2b in spines. Moreover, subunits of the NMDA receptor were differently distributed in FILIP-expressing neurons, and excitation propagation was altered in FILIP-knockout mice. These results indicate that FILIP is a novel, region-specific modulator of myosin 2b.

Item Type:	Article (Journal)
Additional Information:	5128/38350
Uncontrolled Keywords:	Molecular, neuroscienc,e Cellular neuroscience, Brain
Subjects:	Q Science > QP Physiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science
Depositing User:	Dr Mohammad Tariqur Rahman
Date Deposited:	19 Sep 2014 16:11
Last Modified:	11 Jun 2018 15:00
URI:	http://irep.iium.edu.my/id/eprint/38350

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