Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application

Mahmood, Syed and Bakhtiar, M. Taher and Mandal, Uttam Kumar (2014) Experimental design and optimization of raloxifene hydrochloride loaded nanotransfersomes for transdermal application. International Journal of Nanomedicine, 2014 (9). pp. 4331-4346. ISSN 1178-2013

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Abstract

Raloxifene hydrochloride, a highly effective drug for the treatment of invasive breast cancer and osteoporosis in post-menopausal women, shows poor oral bioavailability of 2%. The aim of this study was to develop, statistically optimize, and characterize raloxifene hydrochloride-loaded transfersomes for transdermal delivery, in order to overcome the poor bioavailability issue with the drug. A response surface methodology experimental design was applied for the optimization of transfersomes, using Box-Behnken experimental design. Phospholipon ® 90G, sodium deoxycholate, and sonication time, each at three levels, were selected as independent variables, while entrapment efficiency, vesicle size, and transdermal flux were identified as dependent variables. The formulation was characterized by surface morphology and shape, particle size, and zeta potential. Ex vivo transdermal flux was determined using a Hanson diffusion cell assembly, with rat skin as a barrier medium. Transfersomes from the optimized formulation were found to have spherical, unilamellar structures, with a homogeneous distribution and low polydispersity index (0.08). They had a particle size of 134

Item Type:	Article (Journal)
Additional Information:	5209/38263
Uncontrolled Keywords:	transfersomes, raloxifene hydrochloride, RSM, Box-Behnken, transdermal flux
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Dr Muhammad Taher
Date Deposited:	15 Sep 2014 12:21
Last Modified:	25 Aug 2017 16:01
URI:	http://irep.iium.edu.my/id/eprint/38263

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