Nanostructured material from hydroxyethyl cellulose for skin tissue engineering

Zulkifli, Farah Hanani and Jahir Hussain, Fathima Shahitha and Abdull Rasad, Mohammad Syaiful Bahari and Mohd Yusoff, Mashitah (2014) Nanostructured material from hydroxyethyl cellulose for skin tissue engineering. Carbohydrate Polymers, 114. pp. 238-245. E-ISSN 0144-8617

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Abstract

tIn this study, a novel fibrous membrane of hydroxyethyl cellulose (HEC)/poly(vinyl alcohol) blend wassuccessfully fabricated by electrospinning technique and characterized. The concentration of HEC (5%)with PVA (15%) was optimized, blended in different ratios (30–50%) and electrospun to get smoothnanofibers. Nanofibrous membranes were made water insoluble by chemically cross-linking by glu-taraldehyde and used as scaffolds for the skin tissue engineering. The microstructure, morphology,mechanical and thermal properties of the blended HEC/PVA nanofibrous scaffolds were characterized byscanning electron microscope, Fourier transform infrared spectroscopy, differential scanning colorime-try, universal testing machine and thermogravimetric analysis. Cytotoxicity studies on these nanofibrousscaffolds were carried out using human melanoma cells by the MTT assays. The cells were able to attachand spread in the nanofibrous scaffolds as shown by the SEM images. These preliminary results showthat these nanofibrous scaffolds that supports cell adhesion and proliferation is promising for skin tissueengineering.

Item Type:	Article (Journal)
Additional Information:	4701/38236
Uncontrolled Keywords:	Electrospinning, Hydroxyethyl cellulose, Nanofibrous, scaffolds, Skin tissue engineering
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011) Kulliyyah of Allied Health Sciences
Depositing User:	Dr. Mohammad Syaiful Bahari Abdull Rasad
Date Deposited:	12 Sep 2014 11:28
Last Modified:	08 Jun 2022 16:31
URI:	http://irep.iium.edu.my/id/eprint/38236

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