Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis

Abdul Aziz, Mohd. Hafiz and Udy, Andrew A. and Wallis, Steven C. and Roberts, Michael S. and Lipman, Jeffrey and Roberts, Jason A. (2014) Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis. In: 24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2014), 10th-13th May 2014, Barcelona, Spain.

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Abstract

Critically ill patients with sepsis can develop profound pathophysiological changes that may alter antibiotic pharmacokinetics (PK) and produce sub-therapeutic concentrations at the sites of infection leading to therapeutic failure. We aimed to describe the plasma PK of piperacillin and its associated penetration into interstitial fluid (ISF) of subcutaneous tissue. We also sought to describe risk factors for not achieving PK/pharmacodynamic (PK/PD) targets in critically ill patients with sepsis.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	6561/37925
Uncontrolled Keywords:	Plasma & subcutaneous tissue pharmacokinetics of piperacillin
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User:	Mohd Hafiz Abdul Aziz
Date Deposited:	19 Nov 2015 09:38
Last Modified:	25 Jun 2018 09:00
URI:	http://irep.iium.edu.my/id/eprint/37925

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