Ethanol modified supercritical carbon dioxide extraction of antioxidant rich extract from Pereskia bleo

Sharif, K. M. and Rahman, Md. Mokhlesur and Azmir, Jannatul and Shamsudin, Siti Hadijah and Uddin, Md. Sayed and Fahim, T. K. and Sarker, Md. Zaidul Islam (2015) Ethanol modified supercritical carbon dioxide extraction of antioxidant rich extract from Pereskia bleo. Journal of Industrial and Engineering Chemistry, 21. pp. 1314-1322. ISSN 1226-086X

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Abstract

Supercritical fluid extraction (SFE) of Pereskia bleo leaves was carried out with systematic experimental study to screen and optimize the factors affecting yield and antioxidant activity. Initially, five factors were studied by Plackett–Burman study to screen the most influential factors. Consequently, three significantly affecting factors were optimized by Box–Behnken study. At the optimum condition (52 °C, 36 MPa and 1.5% ethanol of total CO2) yield and IC50 value obtained by SFE were higher than water extract and lower than methanol extract. GC–MS analysis showed that the ethanol modified supercritical carbon dioxide has increased efficiency for extracting antioxidant compounds, α-tocopherol, β-sitosterol and erythritol.

Item Type:	Article (Journal)
Additional Information:	5269/37115
Uncontrolled Keywords:	Supercritical fluid extraction; Antioxidant activity; Modifier
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Mohd Mokhlesur Rahman
Date Deposited:	02 Jul 2014 09:28
Last Modified:	22 May 2018 10:14
URI:	http://irep.iium.edu.my/id/eprint/37115

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