Perinatal programming of hypertension on exposure to high and low sodium chloride diet during pregnancy and lactation in Sprague-Dawley rats

Aminuddin, Niferiti and Abdul Razak, Tariq and Azzubaidi, Marwan Saad and Tin, Myo Han and Mohd Noor, Noriah (2014) Perinatal programming of hypertension on exposure to high and low sodium chloride diet during pregnancy and lactation in Sprague-Dawley rats. In: 11th Annual Scientific Meeting Malaysian Society of Hypertension (MSH 2014), 17- 19 January 2014, Kuala Lumpur, Malaysia. (Unpublished)

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Abstract

Background: Adverse conditions in utero may lead to hypertension during in later life, however inconsistency of the result has been reported. Objective: This experiment aims at studying the effects of high and low maternal dietary sodium on their offspring’s blood pressure at 4 and 8 weeks. Materials and methods: Normotensive female rats were subjected to timed pregnancy. Pregnant rats were randomly divided into three groups and were fed either low-sodium diet (LSD) (0.145%NaCl) (n=10), normal-sodium diet (NSD) (1.0%NaCl) (n=10) or high-sodium diet (HSD) (3.0%NaCl)(n=10) during pregnancy and 4 weeks of lactation. The offsprings were weaned at 4 weeks old. Thereafter, all the three groups were fed with normal-sodium diet (1.0%NaCl) for another 4 weeks. Results: At 4 weeks old, the offsprings of HSD dams have significantly higher systolic blood pressure(SBP) compared to NSD group respectively (119.44mmHg ±1.8 vs 103.65mmHg ±0.92). There were no differences in the offspring’s SBP between NSD and LSD dams at 4 weeks old. Nevertheless, at 8 weeks old, the offspring’s of LSD dams have significantly higher SBP as compared to NSD dams (130.13±1.45mmHg vs 120.26mmHg±1.09). Similarly, at 8 weeks old, the offspring of HSD dams have significantly higher SBP as compared to NSD dams 131.06±1.49mmHg vs 120.26mmHg±1.09). The offspring’s heart rate, average food intake and body weight were similar between all the three groups at 4 and 8 weeks. Conclusions: This suggests that the offspring of both HSD and LSD have greater propensity to develop higher blood pressure and it is pertinent to consider optimum dietary sodium consumption during. pregnancy.

Item Type:	Conference or Workshop Item (Speech/Talk)
Additional Information:	6809/34805
Subjects:	Q Science > QP Physiology R Medicine > R Medicine (General) R Medicine > RG Gynecology and obstetrics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy
Depositing User:	Dr. Marwan Saad Azzubaidi
Date Deposited:	18 Feb 2014 11:50
Last Modified:	12 Dec 2014 15:43
URI:	http://irep.iium.edu.my/id/eprint/34805

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