Preparation of metformin HCl microspheres and encapsulation efficiency

Ahmad, Kausar and Ruslan, Ruhaini and Mohamed, Farahidah and Elsaid Ali, Aimen Abdo (2013) Preparation of metformin HCl microspheres and encapsulation efficiency. In: International Conference and Exposition of Invention on Institutions of Higher Learning (PECIPTA 2013), 7th-9th Dec. 2013, Kuala Lumpur Convention Center (KLCC), Kuala Lumpur.

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Abstract

Due to the pharmacokinetic properties, metformin HCl needs longer period to achieve therapeutic effects with multiple daily doses which may reduce patient’s adherence towards the medication. Hence, novel drug delivery system such as microspheres may be helpful for this non-compliance of the conventional therapy. Double-emulsion solvent evaporation technique was employed in this work since Metformin HCl is a hydrophilic drug. PLGA and PVA of specific characteristics were used. A total of 30 formulations were prepared by varying the concentration of metformin and different conditions. The procedure employed resulted in spherical and free-flowing microspheres with acceptable particle size for drug delivery. Maximum encapsulation efficiency observed was 15%. The concentration of metformin used influenced the encapsulation efficiency among other factors. Higher values, which is desirable for dosage form, may be obtained by manipulating the parameters such as the molecular weight of PLGA.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	4551/34545
Uncontrolled Keywords:	Metformin, microspheres, diabetes, PLGA, encapsulation
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	DR KAUSAR AHMAD
Date Deposited:	22 Oct 2015 15:16
Last Modified:	22 Oct 2015 15:16
URI:	http://irep.iium.edu.my/id/eprint/34545

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