Anti-inflammatory activities of Cinnomomum burmanni Bl

Khatib, Alfi and Mi-Yeon, Kim and Shin-Kyo, Chung (2005) Anti-inflammatory activities of Cinnomomum burmanni Bl. Food Science and Biotechnology, 14 (2). pp. 223-227. ISSN 2092-6456 (O), 1226-7708 (P)

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Abstract

Anti-inflammatory assay was conducted on 20 kinds of traditional Indonesian medicinal herbs using soybean lipxygenase (SLO) and hyaluronidase (HAse). C. burmanni Bl showed highest anti-inflammatory activity. Ethyl acetate fraction from methanol extract of C. burmanni Bl bark showing highest SLO inhibitory activity was isolated using silica gel-60 column chromatography. Two compounds were isolated and purified through preparative HPLC. Through analysis of UV, 1H-NMR, 13-C NMR, EI-MS and FAB+-MS, compounds 1 and 2 were identified as coumarin and 2-hydroxy cinnamaldehyde, respectively, among which 2-hydroxy cinnamaldehyde showed SLO inhibitory activity of IC50=60mikroM. Both compounds did not exhibit HAse inhibitory activity.

Item Type:	Article (Journal)
Additional Information:	6915/33756
Uncontrolled Keywords:	soybean lipoxygenase, coumarin
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. Alfi Khatib
Date Deposited:	30 Dec 2013 11:41
Last Modified:	30 Dec 2013 11:41
URI:	http://irep.iium.edu.my/id/eprint/33756

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