Application of TLC-based metabolomics to identify bioactive compounds possessing adenosine A1 receptor binding activity in Misai Kucing (Orthosphon stamineus) leaves

Khatib, Alfi and Yuliana, Nancy Dewi (2013) Application of TLC-based metabolomics to identify bioactive compounds possessing adenosine A1 receptor binding activity in Misai Kucing (Orthosphon stamineus) leaves. In: 27th Scientific Meeting of Malaysian Society of Pharmacology and Physiology (MSPP2013), 6-8 Sep 2013, MS Garden Kuantan.

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Abstract

A novel approach to identify compounds possessing adenosine A1 receptor binding activity in the leaves of Misai kucing (Orthisphon stamineus) was developed. In this study, adenosine A1 receptor binding, which is related to the diuretic action in the treatment of kidney stones was tested. A combination of thin layer chromatography of different extracts prepared by extraction with diverse solvents (n-hexane, chloroform, n-butanol and water), and multivariate data analysis based on orthogonal partial least squares proved to be a promising approach to determine these active compounds. Several methoxy flavonoids, fatty acids or terpenoids were estimated to be related o this activity. The results of this study support the traditional use of O. stamineus to treat kidney stone in Malaysia.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	6915/33290
Uncontrolled Keywords:	adenosine, kidney stone, multivariate data analysis, metabolomics, orthosiphon staminues, TLC
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. Alfi Khatib
Date Deposited:	16 Dec 2013 11:09
Last Modified:	16 Dec 2013 11:09
URI:	http://irep.iium.edu.my/id/eprint/33290

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