A preliminary investigation of chitosan film as dressing for punch biopsy wounds in rats

Khan, TanveerAhmad and Peh, Khiang K. (2003) A preliminary investigation of chitosan film as dressing for punch biopsy wounds in rats. Journal of Pharmacy and Pharmaceutical Sciences, 6 (1). pp. 20-26. ISSN 1482-1826

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Abstract

Purpose. To investigate the wound healing efficacy of two chitosan films, Chit-AA and Chit-LA, in comparison with a commercial preparation, Omiderm® using punch biopsy wounds in rats. Methods. The punch biopsy wounds were created in the abdominal region of male Wistar rats. The films were evaluated in terms of transparency, flexibility, adherence property, ease of removal from wounds without damaging underlying tissues and fluid accumulation. In addition, the wounds were examined for dryness, exudation, contraction, period of epithelialization and scar formation. Results. Chit-AA, Chit-LA and Omiderm® films were comparable in terms of transparency, flexibility, adherence property, ease of film removal from wounds without damaging underlying tissues and fluid accumulation. Although there was no statistically significant difference in wound dryness and exudation between the film treated wounds and untreated wounds (Control), a significant difference was obtained in complete wound closure (t100%), period of epithelialization and scar formation. Conclusions. Both Chit-LA and Chit-AA were able to promote wound healing with minimal scar formation.

Item Type:	Article (Journal)
Additional Information:	EMTREE medical terms: animal experiment; animal tissue; article; controlled study; drug efficacy; drug formulation; dry skin; epithelization; film coating; male; nonhuman; powder; punch biopsy; rat; scar formation; skin injury; wound closure; wound dressing
Uncontrolled Keywords:	3914/30841
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy
Depositing User:	Nor Fathiah Jumiran (Part Time)
Date Deposited:	03 Aug 2013 15:14
Last Modified:	04 Aug 2013 18:05
URI:	http://irep.iium.edu.my/id/eprint/30841

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