Microencapsulation of Cassia Alata: fabrication and characterization

Alfatama, Mulham and Ahmad, Kausar and Mohamed, Farahidah (2012) Microencapsulation of Cassia Alata: fabrication and characterization. International Journal of Pharmacy and Pharmaceutical Sciences, 4 (4). pp. 219-224. ISSN 0975-1491

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Abstract

Senna alata or Cassia alata (C. alata) is a plant belonging to the family Leguminosae and has been documented to have antifungal and antimicrobial activities. This research aims to extract C. alata, followed by microencapsulation by solvent-evaporation using biodegradable PLGA. The microsphere is envisaged to release the extract in a controlled manner allowing more convenient mode of administration when treating related skin infection. Several variables had been investigated including different types of surfactants and buffer systems and different homogenization times for primary emulsion. It was found that, most of the surfactants employed resulted in low encapsulation efficiency (<10%). However with 3% poly vinyl alcohol (PVA), slightly higher encapsulation efficiency of 11% was achieved, with size distribution of 7-13 μm. The encapsulation efficiencies were significantly improved (45-64.4%) when the hardening tank was buffered to pH 7, with minimal effect on particle size. Additionally, in-vitro controlled release formulation of C. alata microsphere was demonstrated for duration of almost a month.

Item Type:	Article (Journal)
Additional Information:	4551/26947
Uncontrolled Keywords:	Cassia alata; PLGA; Microspheres; Solvent evaporation; Anti-infective
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	DR KAUSAR AHMAD
Date Deposited:	19 Nov 2012 16:17
Last Modified:	16 Jun 2014 10:44
URI:	http://irep.iium.edu.my/id/eprint/26947

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